Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 4 (vIRF4) Perturbs the G1-S Cell Cycle Progression via Deregulation of the cyclin D1 Gene.

نویسندگان

  • Hye-Ra Lee
  • Jaba Mitra
  • Stacy Lee
  • Shou-Jiang Gao
  • Tae-Kwang Oh
  • Myung Hee Kim
  • Taekjip Ha
  • Jae U Jung
چکیده

Kaposi's sarcoma-associated herpesvirus (KSHV) infection modulates the host cell cycle to create an environment optimal for its viral-DNA replication during the lytic life cycle. We report here that KSHV vIRF4 targets the β-catenin/CBP cofactor and blocks its occupancy on the cyclin D1 promoter, suppressing the G1-S cell cycle progression and enhancing KSHV replication. This shows that KSHV vIRF4 suppresses host G1-S transition, possibly providing an intracellular milieu favorable for its replication.

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عنوان ژورنال:
  • Journal of virology

دوره 83 13  شماره 

صفحات  -

تاریخ انتشار 1998